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EXHIBIT ID: CI_C_0437

Progression of Blood Clot

Progression of Blood Clot

Sequential illustration showing the progression of a blood clot beginning with the initial formation of the clot caused by platelets and fibrin ensnaring red blood cells, growth of the clot as more red blood cells are ensnared by the fibrin web, and the eventual breaking off of portions of the clot creating emboli in the bloodstream.